Overreaction seen in some COVID-19 patients.Ġ2 Gerald Pao, a staff scientist in the Hunter lab, will work Test whether cytokines, like LIF, play a role in the immune Inhibitory factor) plays a role in pancreatic cancer. Inflammatory proteins called cytokines, colloquially known asĪ “cytokine storm.” American Cancer Society Professor Tony Hunter previously showed that the cytokine LIF (leukemia Read more here»Īverting Cytokine Storms and Designing New Tests and TreatmentsĠ1 In severe COVID-19 cases, immune cells in the infected windpipe and lungs can release high levels of damaging At the same time, clinicians can sequence the virus, providing valuable information on the spread of COVID-19 mutations and variants. If successful, this approach could beĮxtended to treat other RNA viruses in the future.Ġ2 In addition, Izpisua Belmonte led a team of multi-institution scientists to develop a new viral screening test that can not only diagnose COVID-19 in a matter of minutes with a portable, pocket-sized machine, but can also simultaneously test for other viruses-like influenza-that might be mistaken for the coronavirus. Of an individual’s COVID-19 infection and limiting the virus’Ĭhances of spreading. This treatment will prevent the virusįrom replicating in the body, thereby reducing the severity RNA-targeting CRISPR-Cas technology to destroy the Levels in the lungs alter the course of the disease.Ġ1 Professor Juan Carlos Izpisua Belmonte is collaborating withĪ San Diego biotechnology company to develop COVID-19 If genetic alterations in pathways that control surfactant The study willĬompare surfactant levels with the health outcomes ofĬOVID-19 patients to determine if a drop in surfactants isĪssociated with more severe disease. Will examine changes in the levels and composition of Physicians at UC San Diego and the VA hospital, Kaech Inside the lungs during a COVID-19 infection.Ġ3 In a separate study, in collaboration with pulmonary Research Institute, will examine the role of memory T cells Her lab, in collaboration with The Scripps

Therefore be excellent targets for vaccines to enable longterm Kaechīelieves that immune cells called memory B and T cellsĪre likely critical for controlling the infection, and could In vaccinated individuals to establish benchmarks forĠ2 Creating a protective coronavirus vaccine isĬurrently one of the world’s greatest challenges. T cells that COVID-19 vaccines will need to re-create Work will be critical to understanding the types of memory If and how long-term immunity can be established. The types of memory T and B cells that form in the lungįollowing SARS-CoV-2 infection as a way to understand Scripps Research Institute and La Jolla Institute to study Influenza and now COVID-19, will collaborate with The 01 Professor Susan Kaech, who studies how we develop immunity to severe viral infections, such as

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